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The EMA notes that the condition is still rare, but due to the high number of people taking semaglutide drugs like Rybelsus, patients should be aware of this potential side effect

Adipose Tissue Location Approximately 85% of total adipose tissue mass, in lean or obese humans, is subcutaneous while the remaining 15% constitutes intra-abdominal fat, including both visceral and retroperitoneal adipose depots

8 Therefore, given the increasing burden of lean MASLD in some populations and the benefits of GLP-1RA in weight management, more clinical attention is warranted

The study that raised these concerns had several limitations: Additionally, the average age of participants was 47 years a group where acne is typically less common