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Nevertheless, sulphasalazine has been demonstrated to be an effective treatment in cancer models, by inhibiting xCT to activate ferroptosis 232,233 and restore sensitivity to chemotherapy

The cellular mechanism of glucocorticoid acceleration of fetal lung maturation

While direct human trial data on this specific interaction remain limited, the biological plausibility is strong enough that the American Association of Clinical Endocrinology (AACE) recommends monitoring liver function when hypothyroid patients on levothyroxine become transiently overreplaced