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Therapeutic strategies aiming to upregulate POLG expression or augment its enzymatic activity may improve mtDNA integrity

Improving RNA-Seq expression estimates by correcting for fragment bias

1,56 (DCX is a microtubule-associated protein that is expressed by neuronal precursor cells and immature neurons in embryonic and adult cortical structures while actively dividing, with neuronal daughter cells continuing to express DCX for 23 wk as the cells mature into neurons.) Oxidative stress, a common feature in several neurodegenerative conditions, plays a key contributory role in the progressive nature of diseases like PD and AD as well as in acute disorders such as stroke and traumatic brain injury (TBI)

236,237 Insulin not only directly lowers blood glucose levels but also further inhibits glucagon secretion from -cells through a feedback mechanism