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Equally important is psychological readiness

Still, some early clinical findings hint at potential uses in more specific contexts: Perioperative brain protection: A randomized controlled trial involving 155 liver surgery patients found that ALA reduced oxidative brain injury from anesthesia (sevoflurane) and improved cognitive recovery scores after surgery.31 Neurodegenerative conditions: In a small trial, ALA appeared to slow brain atrophy in patients with secondary progressive multiple sclerosis over a two-year period.32 While promising, this outcome still needs further confirmation

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It is suggested that increased NOX activity induced by SE or trauma increases steady-state levels of H 2 O 2 directly and indirectly by utilizing NADPH needed for glutathione reduction, leading to the inhibition of glycolysis and increased cell susceptibility to oxidative stress