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Lazo-Porras, M

Excessive release of glutamate and its binding with NMDA, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or kainite (KA) receptors promotes excitotoxicity cell injury with a consequent activation of many molecular pathways, resulting in intracellular calcium (Ca 2+ ) overload 90,91 , reactive oxygen species (ROS) production, mPT, and cell swelling with brain edema 92

Other medications may impair tissue repair, deplete nutrients, disrupt sleep, or increase systemic inflammation, which can make pain more persistent despite temporary symptom relief

Folic acid along with Vitamin B12 helps to control high levels of homocysteine in the blood as elevated homocysteine levels might increase the risk of heart diseases