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As defined by Congress in the Orphan Drug Act and Amendments of 1988, a medical food is to be used only in patients receiving active and ongoing medical supervision including instructions on its use as it may change over time
EDCs may affect obesity because some of these compounds have the ability of both disrupting endocrine homeostasis and inducing metabolic dysregulation, thus promoting adipogenesis, morphofunctional changes in the adipose tissue, and alterations in key regulatory pathways involved in the neural control of appetite, satiety, and energy balance [6,7,8]
This validation highlights the reliability and relevance of the developed in vitro platform for exploring mechanistic toxicological effects
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