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Notably, CDO1, a key regulator of cellular redox balance, has been identified as a ferroptosis-related therapeutic target in OA via integrated multi-omics analyses (Zhao et al., 2025)

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Inside the cell, metal reductase six-transmembrane epithelial antigen of prostate 3 reduces trivalent iron ions to Fe 2+ , which are then released from the lysosome into the cytoplasm via solute carrier family 11 member 2 for participation in various subsequent physiological and biochemical processes [37, 38]