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Study Methodology Inclusion criteria included: BMI over 25 Age between 45 to 70 years No supplement consumption in the past three months No weight loss diet in the past three months No participation in other intervention programs Willingness to lose weight No history of heart, liver, kidney disease, diabetes, hypothyroidism, rheumatoid arthritis, or surgery After signing the informed consent form, participants were randomly assigned to an intervention group (21 individuals) and a control group (22 individuals)

doi: 10.1124/dmd.114.059352

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As indicated above, NADP + can be generated via the action of cytoplasmic and mitochondrial NAD + kinases