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Entre los mecanismos operativos, se postulan efectos protectores de SEMA sobre el remodelado cardiaco con disminucin de la hipertrofia y la fibrosis con mejora de la funcin mitocondrial, de la funcin microvascular y la reduccin de apoptosis demostrados tanto en modelo experimental como clnico27,28, as como otros efectos metablicos relacionados con la reduccin de masa grasa (fig