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Melanin synthesis is impeded by these effects, and over time, it leads to the smoothening of hyperpigmentation and age spots or a general improvement in overall uneven skin tones

The initial step in the MD workup was examination for mtDNA gene abnormalities by either a targeted analysis for common mutations and/or deletions and/or sequencing of the entire mtDNA genome (Baylor Medical Genetics Laboratory, Houston, TX, USA)