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In the ACHIEVE-3 Phase 3 trial, orforglipron was superior to oral semaglutide on both HbA1c reduction (approximately 2.2 vs 1.4 percentage points) and weight loss

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As FDAs Russell Wesdyk put it during the meeting: Weve never faced a problem of, What is it? Mary Thanh Hai, who directs FDAs Office of New Drugs, made a related point about how little of the grey-market supply chain is subject to any reporting requirement