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Interestingly, hyperplasia of selected EEC subtypes in response to intestinal infection is probably dependent on immune cells, since serotonin (5-HT)-producing cell hyperplasia associated with Citrobacter rodentium infection was absent in mice lacking adaptive immunity (53) and CD4 + T cells were necessary to increase numbers of 5-HT producing enterochromaffin cells during helminth infection (149)

Like other hormones, we tend to produce less of it with age, with the production of DHEA peaking around age 25 30

10.1080/13547500400024768 Biomarkers