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[See Adverse Reactions (6.2).] Use caution in a patient with a history of angioedema to another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with JANUMET XR

These include: Neuroprotection : Reducing oxidative stress and inflammation that contribute to dopaminergic neuron death Mitochondrial support : Enhancing cellular energy production, which is often impaired in Parkinson's Protein clearance : Potentially improving the removal of toxic protein aggregates like alpha-synuclein Metabolic benefits : Addressing insulin resistance and glucose dysregulation, which may influence neurodegeneration However, these potential advantages must be weighed against known adverse effects of GLP-1 receptor agonists

For post-bariatric patients, this is a double-edged sword