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However, RE increases IGF-1 mRNA and IGF-1 peptide production in younger adults which result in increases in muscle DNA and protein content (Adams and Haddad, 2018), especially in those tissues that have capabilities of producing the hormone themselves, such as skeletal muscle (Barclay et al., 1998) and it may be speculated that the effect would be more pronounced in individuals experiencing greater activation of intracellular muscle signaling and subsequent muscle hypertrophy and performance (Velloso, 2008

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