retatrutide mechanism triple agonist glp-1 gip glucagon receptor Glucagon-like peptide-1 receptor: mechanisms and advances in therapy Targeting GLP-1, GIP & GCG

Semaglutide is a single-receptor (GLP-1) agonist, tirzepatide is a dual GLP-1/GIP agonist, and retatrutide is a triple GLP-1/GIP/glucagon agonist

More about this with strategy #3

Neither compound is approved for human therapeutic use in this combination

Sources TRIUMPH trial design paper Diabetes, Obesity and Metabolism Phase 2 trial (NEJM) New England Journal of Medicine Phase 2 T2D trial (Lancet) The Lancet TRIUMPH-4 results Eli Lilly Investor Relations Related reading Retatrutide Calculator: Units & Reconstitution Interactive dose calculator, syringe-unit tables for every reconstitution setup, and projected weight loss by starting weight