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Description

The very low rate constants for direct, glutathione-independent dithiol-disulfide exchange reactions between glutaredoxins and roGFP2 or other protein(S 2 )/protein(SH) 2 couples (despite favorable thermodynamics) are a prerequisite and great advantage for reliable redox measurements in vivo

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Objective markers (IGF-1, metabolic panels, and where tested, biological age) typically show measurable improvement

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Writingreview and editing, and supervision: ML and YZ

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