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This difference is likely to be related to the more tightly packed ECD interface of RAMP2 and CTR, driven by the interactions with P37 Cagri , and the preferential CTR engagement by Cagri via a bypass conformation, as discussed below in the context of CTR complexes

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The landmark SURMOUNT-OSA trial found that tirzepatide reduced the apnea-hypopnea index (AHI), the standard measure of sleep apnea severity, by approximately 50 to 60 percent at 52 weeks (Malhotra et al., New England Journal of Medicine , 2024)

Epicardial steatosis, insulin resistance, and coronary artery disease