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GLP-1 (Glucagon-like peptide-1) receptor agonists like semaglutide (Wegovy) and tirzepatide (Mounjaro) work by regulating appetite and reward pathways in the brain

Furthermore, loss of lean muscle mass, which can occur alongside fat loss if protein intake and resistance exercise are inadequate, further reduces metabolic heat production since muscle tissue is metabolically active and generates significant body heat even at rest

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The microbiome-mitochondrion connection: common ancestries, common mechanisms, common goals