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Conclusion evoke and evoke+ are the first large-scale trials to investigate the disease-modifying potential of semaglutide in participants with early-stage symptomatic AD, including exploration of effects on AD biomarkers and neuroinflammation

In addition to increased levels of EGT, gliK was demonstrated to exhibit significant sensitivity to H 2 O 2 compared to wild-type (Gallagher et al., 2012), and it is speculated that it may be due to interruption of the gliotoxin biosynthetic pathway following the incorporation of GSH, as GliK catalyzes the enzymatic step directly following GliG-mediated GSH conjugation (Figure 3) (Davis et al., 2011)