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Description

This is achieved through direct phosphorylation, leading to the inhibition of ACC and HMG-CoA reductase

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Indeed, the inhibition of complex 1 was observed in many cancer cells (Table 1) and usually leads to reduced mitochondrial OXPHOS and ATP depletion, ultimately resulting in AMPK-mediated activation of catabolic pathways and inhibition of anabolic processes through its regulation of mechanistic target of rapamycin complex 1 (mTORC1) (54)

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