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This is common and not cause for concern at the starting dose

The result of the conditional knockout experiment of SF-1 in mice granulosa cells indicates that the loss of this factor in granulosa cells triggers impaired cumulus expansion, ovulatory impairment, and reduced corpus luteum formation, which altogether suppresses progesterone production (58, 59)

Note that the removal of arginines but not lysines strongly reduces ATP turnover and that the mutation RK does not sustain ATPase activity