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Serious Risks and Warnings Both Zepbound and Wegovy can cause serious adverse reactions, including an increased risk of: Thyroid cancer (specifically medullary thyroid cancer) Acute pancreatitis Acute gallbladder disease Hypoglycemia (low blood sugar levels) Severe gastrointestinal adverse reactions Serious allergic reaction Increased heart rate Diabetic retinopathy complications in patients with type 2 diabetes Suicidal ideation Pulmonary aspiration during deep sedation or general anesthesia Contraindications and Risk Factors People with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take Zepbound or Wegovy

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Funding This work has been supported by grants: Zhejiang Shuren University Basic Scientifc Research Special Funds (KXJ1724104C and 2024XZ013), The opening foundation of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine (SKLID2024KF07) and Talent Introduction Project of Zhejiang Shuren University (KXJ1723105)

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