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Applied Therapeutics: The Clinical Use Of Drugs, 9th ed

They were likely nauseated [and] dyspeptic, and taking what some might call a horse pill three times a day could not have been an easy task

Astaxanthin, as an antioxidant, helps produce immunoglobulins in human cells and shields against free radical damage , thus safeguarding the immune system's defences

The urge to jump to a higher dose faster is understandable, but the titration schedule is designed to balance efficacy with tolerability