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The parenteral administration also halts the progression of neurological damage associated with B12 deficiency, but the complete improvement of the condition may depend on the severity and extent of the deficiency.[12][13] Contraindications & Precautions Cyanocobalamin is contraindicated in those with hypersensitivity to cobalt moiety or cobalamin molecule due to the risk of anaphylaxis.[21] Warnings: The use of cyanocobalamin is warned in patients with early Lebers disease as there have been reports of severe and swift optic atrophy with its administration

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Richies 2015 randomized controlled trial found that daily oral glutathione supplementation at 250 mg or 1,000 mg for six months increased GSH levels by 30-35% in red blood cells, plasma, and immune cells [15]