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[11] In vitro permeation studies show the vehicle allows gradual partitioning of tretinoin into viable epidermis while retaining azelaic acid predominantly in follicles and niacinamide in the upper corneal layers, mirroring their desired sites of action

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This led to visible segregation between the different zones of the meniscus, with the peripheral vascularized zones being the red-red, the inner avascular region as the white-white zone, and the area in between as the red-white zone

TJs Proteins BBB components, particularly TJ proteins such as claudin 5 and occludins, can also serve as BBBP biomarkers due to their release into the blood circulation after stroke (161)