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When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells
[217] Some healthcare providers recommend periodic breaks from melatonin therapy to assess ongoing necessity and prevent potential tolerance development
that is, the gene encoding the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR)
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