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Exogenous citrulline augments this loop because it is not a substrate for arginase, allowing more efficient restoration of the intracellular arginine pool

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GLP-1 receptor agonists are generally administered subcutaneously

While the C-terminus of oxyntomodulin and the receptor ECD/ECL1 was lower resolution in the cryo-EM map, the interaction patterns in the modelled protein and the MD simulations were largely similar to GLP-1, albeit that the nature of some interactions differed due to their differing sequences