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Never stop or change your medication without your doctors guidance

While these variants do not predict exact medication response, they may help provide context for why individual GLP-1 efficacy varies and can support a more personalized conversation with your provider about whether semaglutide or tirzepatide aligns better with your genetic predisposition profile

In the UK, the regulatory pathway for new medicines requires the MHRA to assess comprehensive evidence of safety, efficacy, and quality before granting a marketing authorisation

They should also participate in vigorous muscle-strengthening and bone-strengthening activities at least 3 days per week