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NMDARs require both depolarization, to remove their magnesium block, and glutamate activation, to open their channels, to allow Ca 2+ influx

By adopting precision coating methods like slot-die coating early in development, manufacturers can improve the quality, performance, and manufacturability of transdermal patches

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Duration is equally important: while the first 2-4 weeks are typically the most uncomfortable, symptoms usually stabilize or disappear by week 8-12