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FFAR1 is expressed in the pancreatic -cell, where evidence suggests it can influence glucose-stimulated insulin release (197)

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Intriguingly, although SF3B1 does not possess a direct role in MAPK pathway signal transduction, there is little overlap between tumors with MAPK pathway mutations and SF3B1 -mutated tumors, suggesting that SF3B1 mutations possibly lead to splicing variations of specific genes that can lead to MAPK activation (118)