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Binding activates Gq/11 protein signalling, generating IP3 and DAG second messengers that raise intracellular calcium, triggering exocytosis of stored GH granules and stimulating GH gene transcription

ERK-Yap, extracellular signal-regulated kinase-Yes-associated protein

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4.6 Anti-inflammatory effects in asthma and allergic diseases Asthma and allergic diseases are characterized by chronic inflammation and atypical immune responses, mediated through complex interactions among multiple immune cells, with both innate and adaptive immunity being essential