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NICE Clinical Knowledge Summaries and British Society for Haematology guidelines emphasise the importance of prompt investigation when clinical features suggest deficiency

However, against this hypothesis of a primary defect in lymphatic tissue as the proximal cause of lipedema is that lymphatic vessel function as determined by lymphangioscintigraphy appears normal in many women with early stages of lipedema and only later can reductions in lymphatic flow rate or function be detected in many women with late stage lipedema (54,63,64)

But you should have reasonable expectations, and you should always get medical advice before using supplements

These patients develop mitochondrial dysfunction very early (usually within 30 g) or signs of parent-compound toxicity (e.g