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STK11 / LKB1 and KEAP1 mutations in non-small cell lung cancer: prognostic rather than predictive

The E1435Q, R-domain phosphorylation sites and interacting residues mutants were generated by site-directed mutagenesis using primers from Millipore sigma (Supplementary Table 3) and verified by sequencing (Elim Biopharmaceuticals, Inc)

Normal ranges: Normal IGF-1 levels vary significantly by age: Ages 25-39: 116-358 ng/mL Ages 40-54: 90-360 ng/mL Ages 55+: 71-290 ng/mL Note: These are general reference ranges

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