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2 BA homeostasis in gout pathogenesis 2.1 Clinical manifestations Studies have indicates that patients with hyperuricemia commonly exhibit impaired BA homeostasis ( 2.2 Role of dysregulated BA metabolism in lipid metabolism Reduced BA levels contribute to excessive lipid accumulation

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If a top-tier CDMO encounters a quality failure, a regulatory hold, or operational disruption, the absence of broadly distributed backup capacity means that disruption propagates directly to patients