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In both patients with clinical UC and experimental colitis triggered by DSS in miceferroptosis-related genes were significantly up-and down-regulated, and cellular MDA content FTH and FTL protein levels were increased in IECs, and mitochondrial atrophy and mitochondrial cristae were reduced in colonic IECs of DSS-treated mice (63)
GS-like genes are not just re-deployed, but are re-purposed To explore the catalytic capacity of nematode GS-like genes, the G
Past efforts to intervene in the disease by drugging targets including metabolism, mitochondria, secretases, steroid hormones, and cholesterol had yielded one disappointment after another
Nature 539 , 294298 (2016)
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