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The increased plasma glucose associated with Ex9-39 infusion is, in itself, a driver of insulin secretion

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When activated, MC1R triggers a signaling cascade: MC1R activation cAMP increase cAMP activates MITF (master melanocyte transcription factor) MITF upregulates tyrosinase and related enzymes Pheomelanin production shifts to eumelanin production This last point is the key insight

This receptor activation leads to a rapid burst of growth hormone release