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The mean (SD) reduction of body weight from baseline was 4.74 (1.687) kg on day 29 in 15mg dose cohort compared to 0.45 (1.460) kg in the placebo cohort

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On this page What retatrutide is (the triple agonist bit) TRIUMPH-1: the headline obesity trial TRANSCEND-T2D-1: retatrutide and type 2 diabetes The wider TRIUMPH programme: knee and sleep apnoea ADA 2026 and where approval stands FAQ Key takeaways TRIUMPH-1 showed 28.3% mean weight loss at 80 weeks on the 12 mg dose, versus 2.2% on placebo