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Riboflavin has therapeutic potential for certain mitochondrial disorders, such as mutations in the X-linked apoptosis-inducing factor mitochondria-associated 1 (AIFM1) and mitochondrial complex I deficiency nuclear type 20 or mitochondrial complex II deficiency (43)

Poor vitamin B 12 status has been linked to increased risk of breast cancer in some, but not all, observational studies

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