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Tirzepatide long-term side effects: what four years of data shows SURPASS-CVOT (Nicholls et al., NEJM 2025) provides the longest-term safety data for tirzepatide a cardiovascular outcomes trial with a median follow-up of approximately four years in 13,165 people with Type 2 diabetes and established atherosclerotic cardiovascular disease

Further, dietary CoQ 10 supplementation is recommended to treat cardiomyopathy-associated deficits as well as to compensate its plasma level concentrations usually reduced by therapeutical application of statins

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