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For example, participants in the trials reported side effects that were generally consistent with previous studies, such as gastrointestinal symptoms, which are one of the main reasons that can lead to discontinuation of the drugs

Up to 95% of people will experience facial lesions due to acne during their lifetime, which frequently begins in adolescence but persists or starts in adulthood

32 Contrary to early skin model studies, Hernandez et al 32 found only low or inconsistent levels of ROS and AGEs in systemic models, suggesting that DNA damage is not primarily ROS-mediated and instead may occur through mechanisms such as glycation or crosslinking of DNA repair proteins

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