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10.1016/j.tips.2005.08.008 66 KamoharaS.BurcelinR.HalaasJ

Editorial Notes: This article was edited by a Neuroscience News editor

Most side effects are reversible upon discontinuation of therapy, but serious reactions necessitate prompt evaluation and supportive care

One recent study used CRISPRa to successfully restore neuronal excitability and electrophysiological deficits in Scn2a +/- mice to wild-type levels, an effect that persisted until at least 3 and 8 months, respectively [78]