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These predictive capabilities must be paired with next-generation interventionsincluding spatiotemporally controlled nanomedicine, PROTACs, and immunotherapies targeting CSC/DTP-specific antigens (e.g., TROP2)to synergistically dismantle the tumor's intrinsic survival fortress and extrinsic physical-immune barriers

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Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae