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These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying

However, if skin quality is already poor - and we know for women over 50, or those with stretch marks on the underside of their arm, the skin quality for the back of the arms is poor - CoolSculpting will not be able to tighten or lift that

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Nature 606 , 968975 (2022)