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Information sources and search The literature was explored using the MEDLINE (via PubMed) and Web of Science databases, including all articles published from the inception up February 2020
Dosage form optimization: Controlled-release formulations enabling once-weekly oral administration Indication expansion: NASH, Alzheimers disease, cardiovascular protection Conclusion: A game-changing Molecule Design Orforglipron represents a triumph in small molecule drug designit demonstrates that clever chemical structure design can break through the dominance of biologics
No mutagenic effect has been clearly established in humans
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