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In obese or pre-diabetic people, the physiological GLP-1 responses can be impaired due to factors such as gut health, circadian rhythms, stress, genetics and lifestyle

10.3389/fphar.2022.925993 141 RanF.YangY.YangL.ChenS.HeP.LiuQ.et al (2022)

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GLP-1 is a gut hormone released after eating that signals the brain to reduce appetite, slows gastric emptying (so you feel fuller longer), stimulates insulin release from the pancreas, and suppresses glucagon (which would otherwise raise blood sugar)