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Metformin, through the induction of 5' AMP-activated protein kinase and subsequently insulin sensitivity, has been widely used as a therapeutic agent in various conditions, including type 2 diabetes mellitus, PCOS and gestational diabetes (Reference Rice, Elia and Jawad42)
To evaluate their genuine leukemogenic potential, researchers engineered a lentiviral CRISPR-Cas9 system that can induce the t(11;19)/MLL-ENL translocation in human CD 34+ HSPCs
The test compound was pre-incubated with purified human recombinant 12-LOX or 15-LOX for 1 min
140 mg/kg as the loading dose, and then 70 mg/kg every 4 h for 3 days 76,77
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