flow trial glp 1 Mapping the effectiveness and risks of GLP-1 receptor agonists Long-term kidney outcomes of semaglutide

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Additional consequences of GLP- 1 receptor activation include appetite suppression, cardioprotective effects, and inhibition of glucagon secretion associated with inhibition of gastric emptying [6]

In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions