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To provide the proper cellular context for our mechanistic findings, we tested the PDS5B 17A mutant in biological assays of DNA damage repair, RAD51 focus formation, HR, and replication fork protection and were able to demonstrate that the DNA binding activity is needed for these PDS5B-dependent biological functions

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Aphids Balance Their Diets by Rebuilding Plant Amino Acids Aphids suck up an almost endless supply of sugary sap from their plant hosts

Conclusions Although challenges associated with some of these compounds remain, important advances have been made in the development of safer and more effective drugs that could actually represent a breakthrough for fatal degenerative diseases such as ALS