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These thresholds emerged from clinical trial populations and real-world efficacy data

A CobaSorb test showing a clear increase in holoTC supports a normal uptake, while an increase below a set limit should be taken with some reservation before a conclusion of a permanent impaired uptake of B12 is made

Internalization experiments validated receptor-mediated endocytosis, resulting in cytoplasmic accumulation, while in vivo imaging demonstrated significant tumor targeting and retention, with aptamer Levels in tumors being 50 to 1000 times greater than in other tissues

Moreover, CagriSema produced greater mean reductions in HbA1c [116]