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Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

As the prevalence of obesity and diabetes have reached epidemic proportions in many regions throughout the world (15), such findings underscore the urgent need for targeted therapies addressing brain health in the face of high fat diets, especially during middle age - a period critical for metabolic and cognitive health

It presents a lipid- and water-soluble substance meaning that it is active in both hydrophobic and hydrophilic environments (i.e

Shah P, Ardestani A, Dharmadhikari G et al (2013) The DPP-4 inhibitor linagliptin restores -cell function and survival in human isolated islets through GLP-1 stabilization